anticholinergic drug groups, including bladder antimuscarinics. If you take one, ask whether the benefit still outweighs the risk and whether non-drug measures or lower-anticholinergic options fit your situation.
Patient reviewing an antidepressant medicine with a doctor.
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Identify strongly anticholinergic antidepressants
Some antidepressants, especially older tricyclic medicines such as amitriptyline, imipramine, clomipramine, and higher-dose doxepin, can add a strong anticholinergic effect. The same JAMA Internal Medicine study reported anassociation between anticholinergic antidepressants and later dementia diagnosis. Do not stop an antidepressant abruptly; ask the prescriber whether your dose, diagnosis, and alternatives should be reviewed.
Clinician discussing an antipsychotic medicine review
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